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Image Search Results
Journal: mAbs
Article Title: Quantification of IgG monoclonal antibody clearance in tissues
doi: 10.1080/19420862.2017.1337619
Figure Lengend Snippet: Schematic representation of the PBPK model. The whole body representation shows the included tissues. After injection, antibodies are distributed to the tissues by the blood flows (black arrows). Extravasation into the interstitial space occurs mainly by convection. Alternatively, the antibody can be taken up by the endosome following passive uptake. From the interstitial space, the antibody is then returned to the systemic circulation by the lymphatic system (dashed arrows). In the endosome, the antibody can bind to the FcRn receptor and be recycled to the plasma or, if it does not bind, it might undergo degradation in the lysosome. Upon degradation, the radioactive label might leave the cell fairly quickly in case of a non-residualizing (I-125 / yellow star) label or be trapped in the cell for a certain time in case of a residualizing label (e.g., In-111 / red star). This difference is a good indicator of the extent of degradation.
Article Snippet: Parameter estimation The
Techniques: Injection, Convection, Clinical Proteomics